Photochemical Tissue Passivation Prevents Contracture of Full Thickness Wounds

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Abstract 98: Photochemical Tissue Passivation (PTP) Prevents Contracture of Full Thickness Wounds

PURPOSE: Large surface area wounds, resulting from burns, trauma, or iatrogenic injury, often result in significant scarring and wound contracture. Despite treatment with any of the currently available gold-standard therapies, contracture can still develop as a sequelae of the process of normal wound healing, specifically, myofibroblast activity. Photochemical Tissue Passivation (PTP) is a proc...

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Topical Simvastatin Enhances Tissue Regeneration in Full-thickness Skin Wounds in Rat Models

Wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. Simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. In this study we aimed to determine the effect of simvastatin on wound healing process in...

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Topical Simvastatin Enhances Tissue Regeneration in Full-thickness Skin Wounds in Rat Models

Wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. Simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. In this study we aimed to determine the effect of simvastatin on wound healing process in...

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Does Orientation of Full-Thickness Groin Grafts Affect Hyperpigmentation in Burn Contracture and Syndactyly Hands?

BACKGROUND Some grafts harvested from the groin area do not become hyperpigmented and in an individual with multiple pieces of grafts, the hyperpigmentation of the pieces may vary. This study evaluates the orientation of the inset of groin grafts according to their donor sites (superior-inferior) and its role in graft hyperpigmentation. METHODS Patients with hand burn contracture or syndacty...

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topical nicotinamide improves tissue regeneration in excisional full-thickness skin wounds: a stereological and pathological study

background nicotinamide (na), the active form of vitamin-b3, is hypothesized to have positive effects on the process of wound healing; it has anti-inflammatory, antioxidant, and immunomodulatory properties, as well as an epithelization inducing action. objectives in the present study, we aimed to determine the effects of topical administration of na on skin wounds, based on histomorphometrical ...

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ژورنال

عنوان ژورنال: Journal of the American College of Surgeons

سال: 2017

ISSN: 1072-7515

DOI: 10.1016/j.jamcollsurg.2017.07.773